Paul Tsang

Paul Tsang

Professor
Molecular, Cellular and Biomedical Sciences
Phone: (603) 862-3479
Office: Rudman Hall, Room 187, Durham, NH 03824
Websites:
The major focus in my laboratory is to study the role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in regulating corpus luteum architecture and function. By utilizing northern and western blotting, zymography, in situ hybridization, immunohistochemistry, and cell culture techniques, we have been able to identify the presence of MMPs (gelatinases, membrane-type 1 and TIMPs (e.g., TIMP-1, TIMP-2, TIMP-3) in the cow corpus luteum over the estrous cycle. We have also shown that TIMP-1 and TIMP-2 proteins decrease dramatically in sheep corpus luteum following a one-hour infusion of prostaglandin F2a (PGF2a).

Recently, a second focus in my laboratory is to study age and growth, reproductive cyclicity and genetics of two skate species found in the Gulf of Maine. This information is vital to the development of a fisheries management plan for these two over-fished elasmobranchs.

Utilizing the technique of ultrasonography, we also participate in a regional project examining the regulation of follicle development in cattle.

Courses Taught

  • BCHM 802: Endocrinology
  • BCHM 853: Cell Culture
  • BCHM/BMS 802/702: Endocrinology
  • BIOL 411/411H: Intro Biol: Molecular/Cellular
  • BMCB 753: Cell Culture
  • BMCB/MCBS 795/895: Invest in Molecular & Cell Bio
  • BMS 702: Endocrinology
  • INCO 790: Advanced Research Experience
  • MCBS 997: Seminar
  • MCBS 999: Doctoral Research

Education

  • Ph.D., Biology, Boston University
  • B.A., Anatomy and Physiology, Cornell University

Selected Publications

  • Prohaska, B. K., Tsang, P. C. W., III, D. W. B., Hoffmayer, E. R., Wheeler, C. R., & Sulikowski, J. A. (2018). Effects of delayed phlebotomy on plasma steroid hormone concentrations in two elasmobranch species. JOURNAL OF APPLIED ICHTHYOLOGY, 34(4), 861-866. doi:10.1111/jai.13700

  • Foradori, M. J., Chen, Q., Fernandez, C. A., Harper, J., Li, X., Tsang, P. C. W., . . . Moses, M. A. (2014). Matrilin-1 Is an Inhibitor of Neovascularization. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(20), 14301-14309. doi:10.1074/jbc.M113.529982

  • Williams, L. J., Campbell, M. D., Tsang, P. C. W., & Sulikowski, J. A. (2013). Using estradiol and progesterone concentrations to assess individual variability in the reproductive cyclicity of captive female little skates, Leucoraja erinacea, from the western Gulf of Maine. Fish Physiology and Biochemistry, 39(5), 1089-1099. doi:10.1007/s10695-012-9766-2

  • Bubley, W. J., Sulikowski, J. A., Koester, D. M., & Tsang, P. C. W. (2013). Using a multi-parameter approach to reassess maturity of spiny dogfish, squalus acanthias, following increased fishing pressure in the western north atlantic. Fisheries Research, 147, 202-212. doi:10.1016/j.fishres.2013.06.004

  • Prohaska, B. K., Tsang, P. C. W., Driggers, W. B., Hoffmayer, E. R., & Sulikowski, J. A. (2013). Development of a Nonlethal and Minimally Invasive Protocol to Study Elasmobranch Reproduction. Marine and Coastal Fisheries, 5(1), 181-188. doi:10.1080/19425120.2013.788590

  • Townson, D. H., Tsang, P. C. W., Butler, W. R., Frajblat, M., Griel, L. C., Johnson, C. J., . . . Pate, J. L. (2002). Relationship of fertility to ovarian follicular waves before breeding in dairy cows. JOURNAL OF ANIMAL SCIENCE, 80(4), 1053-1058. Retrieved from https://www.webofscience.com/

  • Ahmad, N., Beam, S. W., Butler, W. R., Deaver, D. R., Duby, R. T., Elder, D. R., . . . Inskeep, E. K. (1996). Relationship of fertility to patterns of ovarian follicular development and associated hormonal profiles in dairy cows and heifers. JOURNAL OF ANIMAL SCIENCE, 74(8), 1943-1952. Retrieved from https://www.webofscience.com/

  • Relationship of fertility to patterns of ovarian follicular development and associated hormonal profiles in dairy cows and heifers. Cooperative Regional Research Project. (1996). J Anim Sci, 74(8), 1943-1952. doi:10.2527/1996.7481943x

  • Hinshelwood, M. M., Corbin, C. J., Corbin, C. J., Tsang, P. C. W., Tsang, P. C. W., Simpson, E. R., & Simpson, E. R. (1993). Isolation and characterization of a complementary deoxyribonucleic acid insert encoding bovine aromatase cytochrome P450. Endocrinology, 133(5), 1971-1977.

  • CALLARD, I. P., FILETI, L. A., PEREZ, L. E., SORBERA, L. A., GIANNOUKOS, G., KLOSTERMAN, L. L., . . . MCCRACKEN, J. A. (1992). Role of the Corpus Luteum and Progesterone in the Evolution of Vertebrate Viviparity. Integrative and Comparative Biology, 32(2), 264-275. doi:10.1093/icb/32.2.264

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  • Most Cited Publications